Well, again, back to the OP's original question. You will not get significantly better life without giving something up in return, assuming that there isn't some unusual situation causing abnormal battery drain. JuiceDefender can help, but it shuts off most radio functions except to sync at intervals, improvements can be slight to moderate (5%-20%) depending on how aggressive you go. If you root and go to a high performance, optimized operating system that is stripped down, like Infection, Tachyon, Tron, Talonm or something similar and you will get some improvement in battery life by underclocking/undervolting, but not significant.
There is no way around the fact that the major battery drainer here is the screen, it easily uses 50-70 percent of your battery in normal use and on 3/4 brightness will drain a battery a 2 hours with moderate use. No software tweaking or radio change is going to do anything to help that.
One more thing to keep in mind, rooting, unlocking, and S-OFF on the Rezound is different than most others. With HTCDev unlock you can root and flash ROMs, that is about it, you only get access to the recovery and ROM filesystem but even to flash kernels (ie. boot.img files) you have to do a little trickery from the command line. Just being unlocked will NOT allow you to flash radios or Hboot (the bootloader) or anything except recovery and ROM software. This is all most people need and it keeps the phone relatively safe from most possibilities of bricking the device well allowing sufficient access to customization for most users. The next step is not to be taken lightly, it is S-OFF and means Security Off, all mechanisms to stop you from doing anything are disabled, you can flash any radio/hboot/recovery/ROM you want at will, and the phone will do nothing to stop you, even if you do it wrong or load the wrong file, the phone will happily agree and brick itself when S-OFF without any warning to you. S-OFF requires a working Ubuntu distribution of Linux, a piece of copper wire, good timing, a little technical knowledge, and an ability to follow instructions to the letter.
Anyways, done spouting off, hope it helps put things into perspective... My recommendation, if you are not up for a new phone in the next few months, grab an HTC branded extended battery and back cover, unlock the phone, install one of the new JellyBean 4.2 or 4.3 ROMs and enjoy your Rezound for a while, it's real potential isn't even close to being unlocked on the stock ROM.