I was also seeing some crazy battery drain as well on every build. What I finally figured out was that for me it was the Twitter widget. In the stats Twitter used more battery than the display.
I've canned the Twitter widget for Tweetcaster, and I'm on build 11 with Juice defender now and couldn't be happier. Huge improvement.
That's not the issue for me. Just checked the battery stats, and Display was on top, then Android System. I have a twitter widget, but I use the official Twitter app, not Tweetcaster or any other 3rd party Twitter app.
The official Twitter app was the one killing my battery. Tweetcaster has provided me the improvement.
I didn't see Twitter show up in the stats until I turned off autosyncing for both Facebook and Twitter, FYI.