Any Android or even iPhones for the matter should be rebooted every 2 days or so. This will help the operating system to run more efficient. This is not just a DX thing. I have a D1 which is the same way.
While I have had very little to no problems with my DX, my father's freezes alot and reboot. I am going to flash the GB leak on his and see if that fixes it. Mine is running soooo good on it. Fast and reliable..... also while not essential, I like to run fix permissions and then reboot every 2 days just to keep it happy!
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Had the OG Droid, rooted it, installed different ROM's... got burned out on all that. Got my Droid X, and it kicked the OG Droid to hell with the speed, overall operation, and "NEED to REBOOT". My X will reboot itself if and when the system needs to. That happens approximately 1 or 2 times per week. Other than that, it runs just fine. I am stock Froyo and not rooted.
Perhaps the problems are with ROOT and themes... and not the hardware or stock OS. Just saying it amazes me how many complain, and when you get the details they have the phone rooted, themes installed, and APP's that require root installed. Could be some conflicts between software happening there.