I try to avoid reboots if at all possible and when I do, I sit the phone down and walk away after starting it.
I actually reboot my phone once a day whether it needs it or not. I found it interesting that Motorola actually recommends this. http://www.motorola.com/hc/2769/verizon/rss/tips/en-US/d0e947b.2769.en-US.html