I had serious lag to the point I almost reverted back to stock during a couple of versions through 5.0.5. I tried different launchers, different tricks, hacks, scripts, etc. and all to no avail. It was so bad at a point that when I was receiving a phone call, the caller hung up before the picture and slider to answer appeared on the screen.
Unusable.
I had been upgrading versions of Cyano just here and there w/o wiping data and cache, sometimes installing Smoked Glass-esque and other themes.
My last upgrade was to 5.0.6.2 - I wiped data/cache (which isn't a problem to do anymore since all your apps are restored automatically, essentially), didn't bother with a theme, and now use the stock Launcher2 vs. Helix2 (I use the Spare Parts option to keep the home screen in memory).
The thing is retarded fast, and it's only o/c'd to 800mhz. Calls are instant, the app drawer is near instant, and there are no problems with any apps loading slowly/reacting slowly.
So, for all with lag, do this: Wipe data and cache ONCE when you install a new version of Cmod then (optionally) install a theme if you choose w/o wiping (make sure your theme is 5.0.6.2 compatable). Use an app killer (I use APK), use Cachemate (set it to clear cache automatically every couple hours), and keep your total number of screens and widgets to a reasonable minimum (they suck memory and clock cycles too!).