I've been using the US Cellular Note 2 for the past few days, I do love it and if it wasn't for the HTC DNA then I would definitely pick this up when it comes to Verizon. Here's what I noticed about this phone so far.
Most phones have been able to fit in my cup holder, which is perfect since it's the only spot in my center console to easily store a phone and be able to glance down at it. The Note 2 is just slightly too wide to fit.
Surprisingly I've adjusted to holding it in two hands rather well, it feels just as natural as using my TB one handed. Of course you really can't use the Note 2 in one hand easily, as you need to readjust your grip in order to reach the pull down, then to press the back or home button.
I'm not on who cares for the physical home button, I get why some people like it but for me I'm used to the capacitive buttons which are a simply touch to activate, so I find myself attempting the same thing on the Note 2, but then have to press is twice because the first time wasn't hard enough. It also offsets your balance of the phone when trying to use it one handed and you need to go back home.
The S-Pen. Great feature, however I think I only took the S-Pen out once. It has the potential to be handy, I have it configured to open up a pop-up note when removed so if I need to make a quick note I just pull the pen out, no need to open an application. As far as normal day to day tasks, you could use it to swipe between screens, to scroll, etc. but it's much easier to use your finger. The pressure sensitivity seems to work well, but I would hardly call it hundreds of varying levels, it seems to be bold, normal, or light. Also, when you try to write very lightly the pen tends to "skip", even though it's still touching the screen it doesn't always register. Honestly, the S-Pen is a neat feature to have, but for me it's basically pointless (along with many of the features they have)
The new touchwiz software has the capability to prevent the display for rotating if you are lying down while looking at the phone. This is great in theory, as I find myself lying down in bed and having to manually disable rotation on my TB, however I found that in a dark room the phone never detected my face, and continued to rotate on it's own.
It is a great phone, now personally I think 5.5" is slightly too big, so I'm hoping the 5" DNA will be the perfect match for me.
FYI, US Cellular's 4G LTE reminds me of Verizon early on. When I get a strong signal I can easily pull 12-16Mbps down and 10-14Mbps up, but when I'm in a fair coverage area I tend to only pull down around 2-3Mbps.