After using the Note 2 for a few days, I've begun to realize that it's slightly too big for me. If I got the Note 2 would I be happy? Of course, but I think having a 5" phone over a 5.5" phone would allow me to fit the phone in my cup holder, it would allow for better one handed operation, and overall it would fit a bit better in my pocket.
Build quality has always seemed higher on HTC devices than Samsung, for instance the One X is a beautiful phone that feels very durable, I can only imagine that the DNA will be almost exactly like that. I prefer the soft touch plastic to the high gloss plastic of Samsung.
Display. The One X has one of the best displays I have ever seen on a smartphone, ever. The DNA will also have a 1080p screen which will look incredible.
No physical home button, which isn't a huge benefit but one that will be much appreciated.
That makes sense and as long as the end user (you) is happy, that is all that really matters ..