If you are running and have set as default the Helixlauncher 1. Would that need to be switched back to the original 2.1 launcher before the 2.2 update?
You shouldn't have to change anything. The update is all automatic, there is nothing you need to do to "prepare" for it. If you feel better about switching launchers then do it, but it's an app. It shouldn't have anything to do with the update.